1Nakarin Inmutto, 1Suttiwat Jeamtrakool, 1Attaporn Jantarangkoon, 1Wittanee Na Chiangmai, 1Suwalee Pojchamarnwiputh

1Chiang Mai University, Chiang Mai, Thailand

 

Background:

To predict microvascular invasion of hepatocellular carcinoma based on tumor margin enhancement of the pre-operative multiphase CT images.

Methods:

53 patients with HCC underwent pre-operative multiphases CT scan were included in this study. Tumor margin enhancing pattern were analyzed in late arterial phase, portovenous phase and delay phase. The CT features including peritumoral enhancement, arterial rim-enhancement, presence of daughter nodule, complete capsule enhancement in portovenous / delay phase and incomplete capsule enhancement in portavenous / delay phase were reviewed and calculation for sensitivity and specificity. Univariate analysis and multivariate analysis were used to identify predictive features for microvascular invasion (MVI)

Result:

In late arterial phase, peritumoral enhancement or presence of daughter nodule were not predictor for MVI. Incomplete capsule enhancement in portovenous phase and delay phase were good predictor for MVI with Odds ratio 29.25 and 33.09, respectively. The sensitivity and specificity for incomplete capsule enhancement in portovenous phase were 69.23% and 96.86%.  The sensitivity and specificity for incomplete capsule enhancement in delay phase were 71.79% and 96.86%.

Conclusion:

Incomplete capsule enhancement in portovenous phase or delay phase were good predictor for MVI.