1Abdulrahman Al Qahtani, 1Man-Deuk Kim

1Severance Hospita-Yonsei University, Seoul, South Korea

Background:

To investigate the efficacy of intra-arterial lidocaine injection for pain control and inflammatory response, after uterine artery embolization (UAE)

Material(s) and Method(s):

41 patients who underwent UAE .

18 patients (control group) underwent UAE without lidocaine; 23 patients (Lidocaine group), 5 mL ( 50 mg) of 1% Lidocaine was administered slowly into each uterine artery through a microcatheter immediately after UAE. Pain scores (NRS), inflammatory markers including WBC, CRP( c-reactive protein) and Neutrophil/lymphocyte ratio (NLR) and fentanyl consumption were assessed.

Result(s):

No statistically significant differences were observed in NRS pain score at each point between the control and study groups at 0, 1, 2, 4, 6, 8, 12 and 24 hours (Table 1).

Significant reduction in inflammatory markers in Lidocaine group such as WBC count, neutrophil count and neutrophil/lymphocyte ratio and CRP ( c- reactive protein), (P = 0.021, P = 0.007, P = 0.015 and P = 0.001) respectively.

During 24 hours post UAE, patients in Lidocaine group used less anti-emetics (47.8%) as compared with control group (88.9%) (P = 0.008).

The cumulative fentanyl doses administered during the first 24 hours following UAE were not statically significant between the two groups (P = 0.05).

Conclusion(s):

Intra-arterial lidocaine administration after UAE did not contribute in reduction of pain or amount of narcotic agent, it contributes to significant reduction in inflammatory markers, and anti-emetics consumption.