1Tao Pan, 1Qi Zhang, 1Jin-He Guo, 1Hai-Dong Zhu, 1Gao-Jun Teng
1Department of Radiology, Nanjing, China
To evaluate the safety and efficacy of endovascular denervation (EDN) using a novel multi-electrode catheter system on insulin sensitivity and glucose metabolism in type 2 diabetes mellitus (T2DM) patients.
Material(s) and Method(s):
Eight patients with T2DM were enrolled in this study. Fasting glucose, insulin, C peptide, hemoglobin A1c, calculated insulin sensitivity (homeostasis model assessment – insulin resistance (HOMA-IR)), and glucose levels during oral glucose tolerance test were measured before and 3 and 6 months after treatment.
Six months after EDN, fasting glucose was reduced from 9.8 ± 1.8 to 6.5 ± 1.1 mmol/L (P < 0.001). Insulin levels were decreased from 13.2 ± 1.3 to 5.3 ± 1.1 mIU/mL (P < 0.001) and C-peptide levels from 5.2 ± 0.5 to 3.1 ± 0.4 ng/mL (P = 0.003). After 6 months, hemoglobin A1c decreased from 8.5 ± 1.0 to 6.7 ± 0.6 (P < 0.001), and HOMA-IR decreased from 6.4 ± 1.1 to 2.2 ± 0.8 (P < 0.001). Additionally, mean 2-hour glucose levels during oral glucose tolerance test were reduced significantly by 2.5 mmol/L (P < 0.001). There were no deaths or instances of myocardial infarction, stroke, transient ischemic attack, or abdominal aortic stenosis.
Primary results from this trial suggest that EDN using the multi-electrode catheter system safely improves insulin sensitivity and glucose metabolism, and as such may represent a novel approach for the treatment of diabetes.